A paradox: Insulin inhibits expression and secretion of resistin which induces insulin resistance
نویسندگان
چکیده
منابع مشابه
Hypothalamic resistin induces hepatic insulin resistance.
Circulating resistin stimulates endogenous glucose production (GP). Here, we report that bi-directional changes in hypothalamic resistin action have dramatic effects on GP and proinflammatory cytokine expression in the liver. The infusion of either resistin or an active cysteine mutant in the third cerebral ventricle (icv) or in the mediobasal hypothalamus stimulated GP independent of changes i...
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This study is aimed to investigate the effect of human resistin on myocyte differentiation and insulin resistance. The human resistin eukaryotic expression vector was stable transfected into C2C12 myocyte cells and was transiently transfected into COS7 cells. The effects of human resistin on cell proliferation, cell cycle, and myogenic differentiation of C2C12 cells were examined. Glucose uptak...
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Sensing of peripheral hormones and nutrients by the hypothalamus plays an important role in maintaining peripheral glucose homeostasis. The hormone resistin impairs the response to insulin in liver and other peripheral tissues. Here we demonstrate that in normal mice resistin delivered in the lateral cerebral ventricle increased endogenous glucose production during hyperinsulinemic-euglycemic c...
متن کاملResistin, glomerular filtration rate, and insulin resistance.
Resistin, Glomerular Filtration Rate, and Insulin Resistance To the Editor: The recent article by Ellington et al1 showed a significant inverse relationship between circulating resistin levels and estimated glomerular filtration rate (eGFR) in hypertensive adults without cardiovascular disease. This association was independent of markers for insulin resistance and inflammation, suggesting that ...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2008
ISSN: 1007-9327
DOI: 10.3748/wjg.14.95